Barbiturates are classified as Schedule II substances, meaning they've definite prospective for Actual physical and psychological dependence and abuse.
secobarbital will reduce the extent or effect of alprazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
secobarbital will minimize the extent or effect of etonogestrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
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lasmiditan, secobarbital. Both increases effects with the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, like alcohol haven't been evaluated in clinical studies. Lasmiditan may bring about sedation, along with other cognitive and/or neuropsychiatric adverse reactions.
secobarbital will lower the extent or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Observe.
secobarbital will reduce the level or effect of norgestrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Moderate CYP3A4 inducers could lower progestin focus; consider usage of additional barrier methods
secobarbital will minimize the level or effect of abiraterone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
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Period of action, which is associated with the speed at which the barbiturates are redistributed all through the body, differs between individuals As well as in precisely the same person from time to time.
secobarbital will minimize the extent or effect of nilotinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
Barbiturates conveniently cross the placental barrier and so are distributed in the course of fetal tissues; the highest concentrations are found in the placenta, fetal liver, and brain. Fetal blood levels method maternal blood levels following parenteral administration.
Nonteratogenic Effects. Stories of infants struggling from long-term barbiturate publicity in utero bundled the acute withdrawal syndrome of seizures and hyperirritability from delivery to a delayed onset of as much as 14 days (see Drug Abuse and Dependence).
If you take way too much SEDATIVE-HYPNOTIC or overdose, simply call your doctor or poison Manage center right away, or get emergency treatment.